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当前位置: 首页 > 产品中心 > Salinity > Gendepot/Fasudil, Monohydrochloride Salt, >99%, BC028/500mg/BC028-500
商品详细Gendepot/Fasudil, Monohydrochloride Salt, >99%, BC028/500mg/BC028-500
Gendepot/Fasudil, Monohydrochloride Salt, >99%, BC028/500mg/BC028-500
Gendepot/Fasudil, Monohydrochloride Salt, >99%, BC028/500mg/BC028-500
商品编号: BC028-500
品牌: Gen depot
市场价: ¥3300.00
美元价: 1980.00
产地: 美国(厂家直采)
公司:
产品分类:
公司分类: Salinity
联系Q Q: 3392242852
电话号码: 4000-520-616
电子邮箱: info@ebiomall.com
商品介绍
Fasudil, Monohydrochloride Salt is a cell-permeable, selective ROCK inhibitor which induces neuroprotection in vitro. Studies suggest that when acting as a ROCK inhibitor, Fasudil reduces neutrophil transendothelial migration by dimi -nishing cytoskeletal rearrangement of endothelial cells. In addtion, Fasudil sig -nificantly protects against MeHg-induced axonal cytoskeletal rearrangment of endothelial cells.
In addition, Fasudil significantly protects against MeHg-induced axonal degeneration and apoptotic cell death in cultured cortical neurons. Alternate studies show that Fasudil plays an important role in osteoblastic differ -entiation of stromal cells via increasing the mRNA expression of collagen-I, osteocalcin, and bone morphogenetic protein-2 (BMP-2). Furthermore, noggin, a BSMP-2 antagonist can reverse the effects on Fasudil induced mRNA expression of collagen-l and osterocalcin. Upon inhibition of Rho-kinase, Fasudil significantly stimulates FGF-2-induced accumulation of vascular enthothlial growth factor (VEGF).
品牌介绍
Gendepot我们为您的自定义规模应用提供各种试剂,化合物,设备和树脂。我们的技术和定制的工作流程解决方案有助于扩展和补充生命科学工具提供商和应用市场的产品组合,例如分子诊断,疫苗生产,基于细胞的测定,大规模DNA / RNA纯化等。