Gendepot/硼替佐米，游离碱，99%，BC010/500 mg/BC010-500
市场价：
¥8200.00
美元价：
4920.00
产品分类：
电生理设备
公司分类：
Electrophysiological
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| Ki | 0.6 nM |
|---|---|
| Targets | 20S proteasome |
| Solubility | 76 mg/mL in DMSO |
| Other Name | MG-341 , PS-341 |
Bortezomib, a boronic acid dipeptide, is a highly selective, reversible inhibitor of the 26S proteasome which primarily functions in the degradation of mis-folded proteins and is essential for the regulation of the cell cycle. Exposure to Bortezomib has been shown to stabilize p21, p27, and p53, as well as the proapoptotic Bid and Bax proteins, caveolin-1, and inhibitor κB-α, which prevents activation of nuclear factor κB-induced cell survival pathways. Bortezomib also promotes the activation of the proapoptotic c-Jun-NH2 terminal kinase, as well as the endoplasmic reticulum stress response. Alteration of the levels of these cellular proteins leads to inhibition of proliferation, migration, and promotion of apoptosis of cancer cells.Bortezomib is shown to penetrate into cells and inhibit proteasome-mediated intracellular proteolysis of long-lived proteins with a concentration that inhibits 50% of the proteolysis of ∼0.1 μM. The average growth inhibition of 50% value for Bortezomib across the entire panel of 60 cancer cell lines derived from multiple human tumors from the US National Cancer Institute (NCI) is 7 nM. Treatment of PC-3 cells with Bortezomib (100 nM) for 8 h results in the accumulation of cells in G2-M, with a corresponding decrease in the number of cells in G1. Bortezomib kills PC-3 cells at 24 and 48 hr with IC50 of 100 and 20 nM, respectively. Bortezomib induces nuclear condensation at 16–24 hr after treatment. Bortezomib treatment leads to PARP cleavage in a time-dependent manner with concentrations as low as 100 nM being effective at 24 hr.
品牌介绍
Gendepot我们为您的自定义规模应用提供各种试剂，化合物，设备和树脂。我们的技术和定制的工作流程解决方案有助于扩展和补充生命科学工具提供商和应用市场的产品组合，例如分子诊断，疫苗生产，基于细胞的测定，大规模DNA / RNA纯化等。
品牌分类
生化试剂
Protein Biochemistry Reagent
蛋白质电泳试剂
抗体
Peptide
实验室必备耗材
Cell Based Assay Kit
Microbiology Reagent
生物分子
DNA Electrophoresis Reagent
IHC Kit and Reagent
蛋白质分离纯化
植物培养
Cell/Tissue Culture
Cloning Reagent
Lab Essential Equipment
Cytokines
分析试剂盒
Biological Buffers
Growth Factor
IP & Reagent
分子生物学试剂
DNA/RNA纯化试剂
Enzymes
ELISA试剂盒和试剂
PCR/RT-PCR Reagent
Protein Assay Reagent
Immunochemical Reagent
蛋白质印迹试剂
转染试剂
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