Gendepot/Angiopoietin-2，人重组蛋白，CHO，CG1003/25 ug/CG1003-025
商品编号：
CG1003-025
品牌：
Gen depot
市场价：
¥7200.00
美元价：
4320.00
产品分类：
抗人
公司分类：
Anti_Human
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| Source | CHO Cells |
|---|---|
| Formulation | 0.22 µm filtered protein solution is in 20 mM MOPS, 150 mM NaCl, 5 mM CHAPS, and in pH 7.5. |
| Purity | >95%, as determined by Coomassie stained SDS-PAGE. |
| Biological Activity | When immobilized (1 µg/ml), Human ANGPT2 is able to bind to human Tie-2 in a dose dependent manner with an ED50 of < 0.5=""> |
| Stability | Unopened vial can be stored between 2°C and 8°C for one month, at -20°C for six months, or at -70°C for one year. For maximum results, quick spin vial prior to opening. The protein can be aliquoted and stored at -20°C to -70°C. Stock solutions can also be prepared at 50 - 100 µg/mL in sterile buffer (PBS, HPBS, DPBS, or EBSS) containing carrier protein such as 0.2 - 1% BSA or HSA and stored in working aliquots at -20°C to -70°C.Avoid repeated freeze/thaw cycles. |
Angiopoietin-2, also known as ANGPT2, is a member of angiopoietins, which plays essential roles in embryonic and postnatal angiogenesis. The structure of the mature form of ANGPT2 contains an N-terminal coiled-coil domain, which mediates multimerization of the protein, along with a C-terminal fibrinogen-like domain, which mediates the receptor binding. Both ANGPT1 and ANGPT2 are ligands for the receptor tyrosine kinase, Tie-2. ANGPT2 appears to exist predominantly as a homodimer, but it is also capable of forming multimers while ANGPT1 predominantly exists as multimers. It has been shown that ANGPT2 is able to promote vascular leakage and neutrophil migration. ANGPT2 can also sensitize TNF-α-induced monocyte adhesion, thus it is considered a proinflammatory factor. Although ANGPT2 is not required for arterial vascular development, its expression in the tissue suggests that it may play a role in the maintenance of these vessels. This conclusion is also supported by the observation that high concentrations of ANGPT2 activate the same survival signaling pathway as ANGPT1 to prevent endothelial cell apoptosis via Tie-2/Akt. Additionally, ANGPT2 was demonstrated to function as an agonist in the absence of ANGPT1, but in its presence it acts as an antagonist. Human ANGPT2 shares 86% amino acid sequence homology with its murine counterpart.
品牌介绍
Gendepot我们为您的自定义规模应用提供各种试剂，化合物，设备和树脂。我们的技术和定制的工作流程解决方案有助于扩展和补充生命科学工具提供商和应用市场的产品组合，例如分子诊断，疫苗生产，基于细胞的测定，大规模DNA / RNA纯化等。
品牌分类
生化试剂
Protein Biochemistry Reagent
蛋白质电泳试剂
抗体
Peptide
实验室必备耗材
Cell Based Assay Kit
Microbiology Reagent
生物分子
DNA Electrophoresis Reagent
IHC Kit and Reagent
蛋白质分离纯化
植物培养
Cell/Tissue Culture
Cloning Reagent
Lab Essential Equipment
Cytokines
分析试剂盒
Biological Buffers
Growth Factor
IP & Reagent
分子生物学试剂
DNA/RNA纯化试剂
Enzymes
ELISA试剂盒和试剂
PCR/RT-PCR Reagent
Protein Assay Reagent
Immunochemical Reagent
蛋白质印迹试剂
转染试剂
显示分类
联络我们
